bioPAC™ is Solv Wellness’s U.S. branding of Anthocran®.
Scientific Studies
GennaMD’s active ingredient, bioPAC™, is backed by three clinical studies.
- Highly standardized cranberry extract supplementation (bioPAC™) as prophylaxis in young healthy subjects with recurrent UTIs.
The standardized cranberry extract, bioPAC™, has high safety and adherence to support its use as a prophylactic UTI measure.
- Supplementation with high titer cranberry extract (bioPAC™) for the prevention of rUTIs in elderly men suffering from moderate prostatic hyperplasia.
bioPAC™ is safe and effective for reducing rUTIs in elderly men with benign prostatic hyperplasia.
- Cranberry supplementation in the prevention of non-severe lower urinary tract infections.
bioPAC™ helps reduce frequency, duration, and symptoms of rUTIs in adults.
Why the PAC in GennaMD is more effective than whole-berry PAC and D-mannose.
GennaMD is consistently tested by third parties to ensure its efficacy and 100% solubility is at its maximum strength. Specific studies demonstrate GennaMD’s active ingredient, bioPAC™, is superior to those of supplements containing D-mannose or Pacran.
Researchers have confirmed cranberry supplements made from only soluble PAC demonstrate higher Anti-Adhesion Activity against uropathogenic bacteria in urine compared to products with insoluble PAC.
GennaMD is bioequivalent to the 100% soluble cranberry juice-based PAC used in the following studies.
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A 36 mg 100% soluble cranberry juice-based PAC supplement provides a more broad-spectrum benefit against UTI-causing bacteria than D-mannose.
100% soluble cranberry juice-based PAC clinical studies.
GennaMD is bioequivalent to the 100% soluble cranberry juice-based PAC used in the following studies.
- 100% soluble cranberry juice-based PAC provides more consistent and broader benefit against UTI bacteria than D-mannose
Clinical study shows 100% soluble cranberry juice-based PAC effectively prevented adhesion of P-type and Type 1 E. coli while D-mannose’s anti-adhesion activity was notably limited.
- Only soluble PACs from concentrated cranberry juice extract are responsible for Anti-Adhesion Activity
Independent research shows the influence of formulation and proanthocyanidins (PAC) solubility on in vitro and ex vivo P-fimbriated E. coli bacterial Anti-Adhesion Activity (AAA).
- Catheter-associated urinary tract infections
Does cranberry have a role in catheter-associated urinary tract infections?
- Target dose for UTI prevention
36 mg/72 mg PAC identified and confirmed as target dose for UTI prevention.
- Asymptomatic bacteriuria after cystoplasty
Effectiveness of a cranberry (Vaccinium macrocarpon) preparation in reducing asymptomatic bacteriuria in patients with an ileal enterocystoplasty.
- Prophylaxis of rUTIs compared with antibiotic
Cranberry syrup vs. trimethoprim in the prophylaxis of recurrent urinary tract infections among children: a controlled trial.
- Variability of commercial cranberry products for the prevention of uropathogenic bacterial adhesion
Although some are very potent, not all cranberry supplements have sufficient active compound to potentially achieve biologically relevant outcomes for urinary tract infection prevention.
- Cranberries for preventing urinary tract infections
Review published in The Cochrane Library, 2012.
- Recurrent uncomplicated urinary tract infections in women
AUA/CUA/SUFU Guideline (2022).